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Pharmaceutical Sciences and Research (PSR)
Published by Universitas Indonesia
ISSN : 24072354     EISSN : 24770612     DOI : https://doi.org/10.7454/psr
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Aims Pharmaceutical Sciences and Research (PSR), an international, peer-reviewed, open access, and official journal from Faculty of Pharmacy, Universitas Indonesia, aims to disseminate research results and findings in Pharmaceutical Sciences and Practices. Major area of interest is natural products in drug discovery and development. We also consider other areas related to pharmaceutical sciences and practices. PSR publishes content in English language to promote the sharing of knowledge to international scholars. PSR publish 5 types of articles: 1. Original article 2. Case report 3. Case series 4. Review article 5. Mini review article Scope Researches in Pharmaceutical Sciences and Practices which are covered by PSR are within these subject areas: - Pharmacognosy and Phytochemistry - Pharmaceutical Chemistry - Pharmaceutical Technology - Pharmaceutical Biotechnology - Clinical Pharmacy - Pharmacology-Toxicology - Social and Administrative Pharmacy, including Pharmacoeconomy
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Articles 7 Documents
 1 
Search results for , issue "Vol. 1, No. 1" : 7 Documents clear
Pemberian Vaksin Melalui Tanaman Transgenik Radji, Maksum
Majalah Ilmu Kefarmasian Vol. 1, No. 1
Publisher : UI Scholars Hub

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Abstract

Vaccines have played an important role in preventive medicine since Edward Jenner discovered that cowpox induced protection against human smallpox. Until recently, a vaccination has meant a needle in the arm. However, with the increasing need for inexpensive, easily administered vaccines, along with the improvements in genetic engineering, the concept of edible vaccines is fast becoming reality. This is especially important in developing countries, where it is estimated that three to five million children die each year from common diseases, which could have easily been prevented with the proper vaccination. Compared to traditional lab-synthesized vaccines, plants are capable of producing proteins at lower cost, and need not be isolated for injection. Plant-based vaccines are also safer than traditional vaccines because they use selected sub-units of the disease rather the attenuated whole disease-causing organism.
Pengaruh Kandungan Pati Singkong Terpregelatinasi Terhadap Karakteristik Fisik Tablet Lepas Terkontrol Teofilin Juheini, Juheini; Iskandarsyah, Iskandarsyah; J.A, Animar; Jenny, Jenny
Majalah Ilmu Kefarmasian Vol. 1, No. 1
Publisher : UI Scholars Hub

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Abstract

In order to make use of pregelatinized Manihot starch in controlled release tablet, the research was done by heating the starch suspension up to its gelatinized temperatur, then dried. The particle size of pregelatinized Manihot starch used were (100-150 mesh) : (150-250 mesh) : smaller than 200 mesh = 3,5 : 1 : 1. The effect of pregelatinized Manihot starch on physical characteristic of Theophyllin controlled relase tablet was known by using 4 formulas containing variety of pregelatinized starch as follows: 30%, 40%, 50%, and 60%. Evaluation on the tablet results including tablet mass and size uniformity, hardness and friability. The result showed that pregelatinized Manihot starch in variable content on these tablet formulas fulfilled the requirement of tablet physical characteristics.
Penyuluhan Penggunaan Oralit Untuk Menanggulangi Diare Di Masyarakat Harianto, Harianto
Majalah Ilmu Kefarmasian Vol. 1, No. 1
Publisher : UI Scholars Hub

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Abstract

Diarrhea is one of the common deseases and a attack any level of ages. Diarrhea can be tuated effectively by using oralit to replace the lost of body water. To increase the use of oralit against diarrhea, this trestment should be socialized to public with undergo a general lecture to enhanced the public knowledges cncerning diarrhea and causing factors, to make a group discussion of senior citizen and public figures to build positive attitude in using oralit, and to demonstrate the processing of oralit/LGG and how to use it to people.
Pemanfaatan Maltodekstrin Pati Terigu Sebagai Eksipien Dalam Formula Sediaan Tablet dan Niosom Anwar, Effionora; Djajadisastra, Joshita; Yanuar, Arry; Bahtiar, Anton
Majalah Ilmu Kefarmasian Vol. 1, No. 1
Publisher : UI Scholars Hub

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Abstract

The Use of Maltodextrin from Wheat Starch as an Exipient in Formula Tablet and Niosom dosage form. Wheat starch normally can be used as a tablet filler only, because the flow rate and binding capacity are not good enough. The wheat starch should be treated as follows : protein and amine free Bogasari wheat flour starch were hydrolyzed by α-amylase enzyme (Liquezym EX®) at variable temperature and time incubation to produce maltodextrin with different Dextrose Equivalent (DE) value. The maltodextrin could be used as tablet binder on wet granulation, tablet filler and binder on direct compress, a proniosom carrier to prepare niosom, a tablet filler, binder and disintegrator on direct compress tablet, a sugar coated tablet material. All of the product used active compound as amodel and the quality were evaluated according to the 4thed. of Indonesian Pharmacopeae and other valid references. The result shows that maltodextrin DE 1–5 could be used as a tablet binder which was processed by wet granulation on 2-5% concentration, as a tablet binder and filler which was processed by direct compress on 30-35%; maltodextrin DE 10-15 could be used as a proniosom carrier then continued to niosom preparation with surfactant composition of 2 mmol (1 mmol for span 60 and 1 mmol for cholesterol). The surfactant and drug concentration of 100 mmol/lt and 5 mmol/lt subsequently was proved to loading the drug as much as 81.28%. Maltodextrin DE 15-20 could be used as a tablet filler, binder and disintegrator at 84%, and starch hydrolyzed of DE 35-40 as a sugar coating which was more economical than sugar.
Optimasi Biotransformasi Total Sterol Limbah Tahu Menggunakan Mycobacterium phlei DSM 43286 Menjadi 1,4-Androstadien-3,17-Dion, Dengan Pengaruh Variasi Konsentrasi Inhibitor A, A’- Dipiridil Kurniadi, Maryati; Tambunan, Usman Sumo Friend; Harmita, Harmita
Majalah Ilmu Kefarmasian Vol. 1, No. 1
Publisher : UI Scholars Hub

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Abstract

Isolation of total sterol from waste product of soy bean cake has been conducted, followed by biotransformation to 1,4-androstadien-3,17-dione (ADD). The waste product consist of; β-sitosterol, stigmasterol, kaemfesterol, which are isolated by column chromatography technique using silica gel as stationary phase and chloroform as mobile phase. Biotransformation was conducted by using Mycobacterium phlei DSM 43286 in the present of α, α’- dipiridil as an inhibitor with concentration of 0,5; 1; 1,5; 2,0 mM. The main product of biotransformation were ADD and pregnenolon. The optimum yield of ADD 0,48% is achieved by adding 1,5 mM α, α’- dipiridil are two hours after addition of substrate and 72 hours of incubation time.
Respon Bioakumulator Eceng Gondok (Eichhornia crassipes) Terhadap Logam Berat Pb dan Cd di Sungai Pegangsaan Dua Rahayu, Sri Teguh; Faradilla, Meutia; Verawati, Ester Yani; Triana, Muchrip
Pharmaceutical Sciences and Research Vol. 1, No. 1
Publisher : UI Scholars Hub

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Abstract

Eichhornia crassipes is one of Indonesia’s wild plant that considered as weed. Its presence can disrupt ecosystems in the river. However, it is proven to absorb Pb and Fe. It is also believed that E.crassipes can absorb other metals such as Hg , Zn , Cu and Cd which were belong to the same group as Pb and Fe. In addition to heavy metal sequestration, Eichhornia crassipes can also absorb pesticide residues. This descriptive research was done to determine the bioaccumulator response to Pb and Cd in Pegangsaan Dua river using Inductively Coupled Plasma method. Bioaccumulator response of Eichhornia crassipes were analyzed from the stem. The results of the study also showed that the Eichhornia crassipes plants were able to accumulate heavy metals of Pb and Cd. The organs most potential to absorb Cd and Pb were stem organ with average point 1 of Cd : 0,056 ppm and Pb : 0,5002 ppm, then the average point 2 of Cd : 0,0328 ppm and Pb : 0,0215 ppm , and the average point 3 of Cd : 0.0143 ppm and Pb : 1,293 ppm . In this end, it is suggested that the stem organ could be developed as bioaccumulation agent.
Uji Toksisitas Fraksi Air Impatiens balsamina Pada Tikus Betina Galur Sprague Dawley Nurqolbiah, Entang; Kusharyanti, Indri; Nurbaeti, Siti Nani
Pharmaceutical Sciences and Research Vol. 1, No. 1
Publisher : UI Scholars Hub

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Abstract

The present study was aimed to predict the level of toxicity of aqueous fraction of Impatiens balsamina by acute toxicity study using OECD guideline 425. Female Sprague Dawley 8-12 week and weight between 140-170 gram were used, the amount of experimental rats were 10 rats. Rats were sequentially administered all the fraction in single dosage (limit test) of 2000 mg/kg body weight and 5000 mg/kg of body weight. All the animals were individually studied for mortality, wellness parameters, food consumption,water consumption, body weight. Histopathological examination was done on the liver and kidney. The result of this study showed that no mortality and no significant changes were observed in wellness parameter, body weight, food consumption, and water consumption at 2000 and 5000 mg/kg of body weight for 48 hour and 14 days. Histopathological examination of fraction treated groups showed lesion of hepatic cells. Based on the result of this research, the researcher conclude that LD50 of aqueous fraction of Impatiens balsamina L was greater than 5000 mg/kg of body weight, which is classified as mild toxic.

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